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KRAS-driven cancers are notoriously difficult to treat due to poor pharmacodynamics of downstream inhibitors and resistance to anti-EGFR drugs. IMP-1 is a post-transcriptional regulator of KRAS mRNA. As a novel therapeutic approach, the targeting of…

This project examines precipitation patterns across the Continental Divide in the southern Canadian Rockies with a focus on precipitation gradients. This thesis is part of the Storms and Precipitation Across the continental Divide Experiment (SPADE…

Oily wastewater caused by marine oil spills brings great harm to the environment. In this work, the application of gas flotation with microbubbles and nanobubbles in separating crude oil droplets from oily wastewater is reported. The experiments…

Point-of-care ultrasonography (POCUS) is the process of operating a compact ultrasound machine at a patient’s location and immediately integrating the images generated into patient care. POCUS can help nurse practitioners (NPs) make more accurate…

Methods for cumulative threat mapping, such as the human footprint, have been rapidly developing to inform the management of biodiversity and ecosystem services. Here, I perform the first comprehensive literature review establishing what methods are…

Obesity is adetrimental health condition that occurs when energy intake, exceeds energy expenditure. Pituitary adenylatecyclase-activating polypeptide (PACAP) regulates energy expenditure, including adaptive thermogenesis, through the hypothalamic-…

Modern science is currently working to characterize the beneficial compounds from mushrooms and their potential as pharmaceutical drugs. In this thesis, eight British Columbian wild mushroom collections (3 species), comprising Fomitopsis pinicola,…

This work investigated the distribution of phosphorus in dairy manure as it relates to particle size and provides experimentally derived insights for improving the management of phosphorus. The data presented here illustrates some aspects of manure…

The aim and objective of the thesis entitled “Interval-valued Pythagorean Fuzzy Decision-Making Models for Evaluating Challenges of Digital Transformation” are as follows: The first objective is to develop new entropy and divergence measures to…

Understanding forest growth and resilience under global climate change is crucial for forest management, to maintain wood supply for future. In this research, I focused on the response and resilience of subalpine fir (Abies lasiocarpa (Hook.) Nut))…

This thesis examines the institutional structures and systems that coordinate everyday home care nursing work, and how they impact development of nurse-patient relationships from the perspective of patients. Using an institutional ethnographic…

Introduction: The health care system in British Columbia places priority on providing teambased primary maternity care. Participation of mothers in planning their care is an essential component of team-based care. Therefore, it is important to…