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Evaluation of selected mushroom extracts, dispiropiperazine and dispiropyrrolizidine derivatives on acetylcholinesterase activity
Digital Document
Evaluation of selected mushroom extracts, dispiropiperazine and dispiropyrrolizidine derivatives on acetylcholinesterase activity
Acetylcholinesterase is a hydrolase enzyme known for its major role in neurotransmission regulation by breaking down the neurotransmitter acetylcholine at the synapse after every electrochemical signal is successfully relayed between two adjacent…
Efforts towards the heterologous expression of echinodol and congeners in the host Aspergillus oryzae
Digital Document
Efforts towards the heterologous expression of echinodol and congeners in the host Aspergillus oryzae
Molecular characterization of the coding region determinant-binding protein interaction with KRAS oncogene mRNA
Digital Document
Molecular characterization of the coding region determinant-binding protein interaction with KRAS oncogene mRNA
Investigating British Columbia wild mushrooms for growth-inhibitory activity
Digital Document
Investigating British Columbia wild mushrooms for growth-inhibitory activity
Purification and characterization of an immuno-stimulatory compound from the water extract of royoporus badius (Pers.) A.B. De
Digital Document
Purification and characterization of an immuno-stimulatory compound from the water extract of royoporus badius (Pers.) A.B. De
Characterization of spliceosome assembly in cyanidioschyzon merolae.
Digital Document
Characterization of spliceosome assembly in cyanidioschyzon merolae.
Exploring growth-inhibitory and immuno-stimulatory activity in British Columbia wild mushrooms and lichens.
Digital Document
Exploring growth-inhibitory and immuno-stimulatory activity in British Columbia wild mushrooms and lichens.
Spiropyrrolizidine and piperazine derivatives: Synthesis and evaluation on kras expression levels in human colon cancer cells
Digital Document
Spiropyrrolizidine and piperazine derivatives: Synthesis and evaluation on kras expression levels in human colon cancer cells
KRAS-driven cancers are notoriously difficult to treat due to poor pharmacodynamics of downstream inhibitors and resistance to anti-EGFR drugs. IMP-1 is a post-transcriptional regulator of KRAS mRNA. As a novel therapeutic approach, the targeting of…
Purification and characterization of growth-inhibitory compounds from 2 genera of British Columbia wild mushrooms: fomitopsis and phaeolus
Digital Document
Purification and characterization of growth-inhibitory compounds from 2 genera of British Columbia wild mushrooms: fomitopsis and phaeolus
Modern science is currently working to characterize the beneficial compounds from mushrooms and their potential as pharmaceutical drugs. In this thesis, eight British Columbian wild mushroom collections (3 species), comprising Fomitopsis pinicola,…
Experimental approach to overexpress pituitary adenylate cyclase activating polypeptide (PACAP) specifically in the hypothalamus
Digital Document
Experimental approach to overexpress pituitary adenylate cyclase activating polypeptide (PACAP) specifically in the hypothalamus
Obesity is adetrimental health condition that occurs when energy intake, exceeds energy expenditure. Pituitary adenylatecyclase-activating polypeptide (PACAP) regulates energy expenditure, including adaptive thermogenesis, through the hypothalamic-…
In search of novel immune-modulatory compounds from British Columbia wild mushrooms and their effectiveness in inflammatory micro-circulation of mice
Digital Document
In search of novel immune-modulatory compounds from British Columbia wild mushrooms and their effectiveness in inflammatory micro-circulation of mice
Investigating phenotypic effects of intron deletion and sisRNA identification in Cyanidioschyzon merolae
Digital Document
Investigating phenotypic effects of intron deletion and sisRNA identification in Cyanidioschyzon merolae
British Columbian wild mushrooms as potent source of novel natural anti-cancer compounds
Digital Document
British Columbian wild mushrooms as potent source of novel natural anti-cancer compounds
PPAR~ regulates insulin secretion in pancreatic ~-cells : evidence from an in-vivo mouse model of ~-cell specific PPAR~ overexpression
Digital Document
PPAR~ regulates insulin secretion in pancreatic ~-cells : evidence from an in-vivo mouse model of ~-cell specific PPAR~ overexpression
Characterization of U2 snRNA associated proteins: Functional analysis of C. merolae Hsh49 protein
Digital Document
Characterization of U2 snRNA associated proteins: Functional analysis of C. merolae Hsh49 protein
Investigating the coding region determinant binding protein-RNA interaction in vitro, in cells and in silico.
Digital Document
Investigating the coding region determinant binding protein-RNA interaction in vitro, in cells and in silico.
The functional characterization of a Haloarcula marismortui putative TrkE
Digital Document
The functional characterization of a Haloarcula marismortui putative TrkE
Archaea, a domain of organisms possibly linked to the ancestry of eukarya and bacteria, displays a dichotomic evolutionary pattern. Haloarcula marismortui (H. marismortui), an archaeon discovered in the Dead Sea, has unique traits enabling survival…
Role of pituitary adenylate cyclase-activating polypeptide in energy expenditure including the thermogenic response
Digital Document
Role of pituitary adenylate cyclase-activating polypeptide in energy expenditure including the thermogenic response
Obesity results when energy intake chronically exceeds energy expenditure, driving accumulation and malfunctioning of white adipose tissue and increasing risk for comorbidity. Brown adipose tissue (BAT) burns energy via adaptive thermogenesis, a…
Pituitary adenylate cyclase-activating polypeptide receptor expression in sympathetic ganglia innervating adipose tissue
Digital Document
Pituitary adenylate cyclase-activating polypeptide receptor expression in sympathetic ganglia innervating adipose tissue
Obesity is a disease that occurs when energy intake exceeds energy expenditure, concomitantly increasing risk of chronic diseases, including metabolic diseases such as diabetes. Research into therapeutics to correct dysregulations in energy balance…
Small molecule growth inhibitors from Albatrellus flettii and Sarcodon scabripes native to British Columbia
Digital Document
Small molecule growth inhibitors from Albatrellus flettii and Sarcodon scabripes native to British Columbia
The first part of this thesis investigated the growth-inhibitory and immunomodulatory potential of six wild Canadian mushrooms. Out of 24 crude extracts, six showed strong growth-inhibitory activity, two exhibited strong immuno-stimulatory activity…
The role of pituitary adenylate cyclase-activating polypeptide in sympathetic regulation of brown adipose tissue function
Digital Document
The role of pituitary adenylate cyclase-activating polypeptide in sympathetic regulation of brown adipose tissue function
Multifaceted investigation of ribonuclease MRP in Cyanidioschyzon merolae: Heat stress response, canonical rRNA processing pathway, structural prediction and mutational analysis
Digital Document
Multifaceted investigation of ribonuclease MRP in Cyanidioschyzon merolae: Heat stress response, canonical rRNA processing pathway, structural prediction and mutational analysis
Investigating the relationship between IMP1 and APE1 in HEPG2 cells
Digital Document
Investigating the relationship between IMP1 and APE1 in HEPG2 cells
Exploration of the cyanidioschyzon merolae intron landscape
Digital Document
Exploration of the cyanidioschyzon merolae intron landscape
The eukaryotic process of pre-mRNA splicing involves the removal of noncoding intron sequences and the fusion of the remaining protein-coding exon sequences. The splicing reaction is catalyzed by the spliceosome, a dynamic multi-megadalton…
Inhibitors of CRD-BP-KRAS RNA interaction
Digital Document
Inhibitors of CRD-BP-KRAS RNA interaction