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British Columbian wild mushrooms as potent source of novel natural anti-cancer compounds
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Abstract |
Abstract
Worldwide, many fungal species have been used for their medicinal properties by various cultures for centuries. Major challenges with cancer chemotherapy, which includes toxicity, non-specificity and several adverse effects have motivated researchers to search for novel anti-cancer compounds from natural sources. Several studies have identified various anti-cancer compounds from mushrooms in many parts of the world, but mushrooms occurring in British Columbia remain unstudied for their anti-cancer activities. In this thesis, five mushroom species were collected, extracted, and assessed for anti-proliferative and immuno-stimulatory activities. Eleven extracts from these species showed anti-proliferative or immuno-stimulatory activity or both. Sodium hydroxide extract from Paxillus obscurisporus exhibited potent anti-proliferative activity and was further purified using size-exclusion and anion-exchange chromatography. Analysis of the relatively pure anti-proliferative fractions suggests the presence of protein and glycoprotein moieties. Further purification and characterisation is needed before these compounds can be tested for biomedical purposes in the future. |
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Persons |
Persons
Author (aut): Barad, Ankush A
Thesis advisor (ths): Lee, Chow
Thesis advisor (ths): Reimer, Kerry
Degree committee member (dgc): Massicotte, Hugues B.
Degree committee member (dgc): Egger, Keith
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DOI |
DOI
https://doi.org/10.24124/2017/1366
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Degree granting institution (dgg): University of Northern British Columbia. College of Science and Management
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Keywords
fungi
Paxillus obscurisporu
anti-cancer compounds
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Number of pages in document: 99
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Use and Reproduction
Copyright retained by the author.
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Rights Statement
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unbc_17354.pdf1.57 MB
6916-Extracted Text.txt183.7 KB
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British Columbian wild mushrooms as potent source of novel natural anti-cancer compounds
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