Digital Document
Digital Document
KRAS-driven cancers are notoriously difficult to treat due to poor pharmacodynamics of downstream inhibitors and resistance to anti-EGFR drugs. IMP-1 is a post-transcriptional regulator of KRAS mRNA. As a novel therapeutic approach, the targeting of…
Digital Document
Following a protracted attempt at voluntary metropolitan planning in the Calgary region, that was characterized by ongoing rural-urban tensions, in 2017, the Government of Alberta mandated seven urban and three rural municipalities to participate on…
Digital Document
Out of pocket (OOP) healthcare expenditures can be burdening for persons of low socioeconomic status. Little is known about socioeconomic, demographic, and health disparity in OOP healthcare expenditures in Canada. This thesis examines the trends of…
Digital Document
Digital Document
Methods for cumulative threat mapping, such as the human footprint, have been rapidly developing to inform the management of biodiversity and ecosystem services. Here, I perform the first comprehensive literature review establishing what methods are…
Digital Document
Obesity is adetrimental health condition that occurs when energy intake, exceeds energy expenditure. Pituitary adenylatecyclase-activating polypeptide (PACAP) regulates energy expenditure, including adaptive thermogenesis, through the hypothalamic-…
Digital Document
Modern science is currently working to characterize the beneficial compounds from mushrooms and their potential as pharmaceutical drugs. In this thesis, eight British Columbian wild mushroom collections (3 species), comprising Fomitopsis pinicola,…
Digital Document
While research continues to establish a connection between shame and complex trauma, there is a lack of understanding on how this is addressed in therapeutic practice. The current research employed a qualitative exploratory research methodology to…
Digital Document
Digital Document
This work investigated the distribution of phosphorus in dairy manure as it relates to particle size and provides experimentally derived insights for improving the management of phosphorus. The data presented here illustrates some aspects of manure…
Digital Document
The aim and objective of the thesis entitled “Interval-valued Pythagorean Fuzzy Decision-Making Models for Evaluating Challenges of Digital Transformation” are as follows: The first objective is to develop new entropy and divergence measures to…