Compliance with fluid restrictions is an important factor in the health and well-being of hemodialysis patients. Non-compliance is a common and increasing problem for patients, leading to morbidity and death. This study aimed to investigate the relationship between socio-demographic factors and fluid compliance among hemodialysis patients. This retrospective, cross-sectional, descriptive study included 153 patients, a majority of whom were residing in an urban location, and were receiving dialysis treatment in a metropolitan area in Northern Alberta, Canada. About 42% were fluid non-compliant. Younger and male patients found more likely to be fluid non-compliant. Patients who resided and received care in metropolitan areas, had median income above $35,000, and attended all dialysis sessions were less likely to be fluid non-compliant. Psychological support, continuous educational interventions, and follow-up to remind patients about the importance of complying with their fluid restrictions are recommended to minimize the risk of fluid non-compliance.